Noopept, which is an acetylproline, contains dipeptide. It’s neuroprotective effects is generally accepted. As a nootropic agent on a dose-for-dose basis, it is said to be 200 to 50,000 more powerful than piracetam. Noopept tablets are currently used for treating cognitive deficiency of cerebrovascular and posttraumatic nature as it has shown to have positive nootropic and cognitive effect in animal models.
According to animal studies that have been conducted so far, noopept has shown to be neuroprotective and helpful in improving and restoring memory. In studies carried out with the Alzheimer’s disease model, it has not only restored spatial memory but also augmented immunoreactivity to the buildup of amyloid. Noopept is quite safe and specific bioavailability for the brain has been exhibited by its pharmacokinetics.
Noopept can for instance be applied over a broader range of pathological conditions since it produces a nootropic effect at much lower concentrations. Besides, it exhibits anxiolytic effects and it is used in the treatment for anxiety. It has been shown that synaptic transmissions in central neurons are affected by noopept. This lessens stress-induced kinases activity, and raises neutrophines expression in rat hippocampus. Also, in normal and Down’s syndrome human cortical neurons, it prevents oxidative damage and apoptosis.
Noopept provides a subtle psychostimulatory effect, in order for this to occur you need the right dose, see our Noopept dosage review. Normally, this neuroprotective effect takes place during several states of cognitive trauma. This entails oxidative stress as well as physical strain. Scientists need to do more research in order to determine the major mechanism that is responsible for Noopept’s neuroprotective effect.
The hippocampus refers to the region of the brain that is responsible for creation of memories as well as consolidation of short-term memory to long-term memory. When it comes to the expression of Nerve Growth Factor and Brain-Derived Neurotopic Factor (abbreviated as NGF and BDNF, respectively), studies also show Noopept to stimulate them in the hippocampus and cerebral cortex.
BDNF is an important protein which determines the quantity of new neurons the brain can create. It is also crucial in regulating growth, survival as well as separation of the existing neurons. On the other hand, the NGF protein is crucial for the survival and preservation of sympathetic nerve and sensory neurons. Studies have indicated that noopept increases NGF levels and this is one of the reasons why it has been alleged that noopept shows a lot of promise to avert the development of Alzheimer’s disease in patients who have a mild cognitive injury.